Expressed Sequence Tags: Clustering and Applications
نویسندگان
چکیده
Iowa State University 12.
منابع مشابه
P-215: Discovery of A Novel APA Variant of A Human Potential Gene Based on Expressed Sequenced Tags Analysis
Background: Expressed sequence tags (ESTs) are sequences of cDNA fragments prepared from different tissue sources. There are over one million of these sequences in the publicly available database, and these sequences are believed to represent more than half of all human genes. The ESTs belong to different cDNA libraries, was prepared from one particular cell type, organ, or tumor. Therefore, th...
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MOTIVATION Expressed Sequence Tags (ESTs) are short single-pass DNA sequences obtained from either ends of cDNA clones. To exploit these sequences efficiently, a dynamic Web-tool has been developed which uses these data to perform fast virtual cloning of cDNAs. RESULTS Starting with a query sequence, the user is able to identify related ESTs and extend the sequence of interest step by step, p...
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This report gives a skeleton description of the d2 algorithm used for the clustering of expressed sequence tags (ESTs) in the wcd program. It describes how the algorithm works and why some design decisions were made. No experimental evidence is reported here. This is subject of ongoing research.
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The d2 distance function is commonly used in the clustering of DNA sequences such as expressed sequence tags (ESTs), an important biological application. The use of d2 allows approximate string matching to be performed with a good balance between selectivity and sensitivity. The computational challenges of EST clustering make the efficient evaluation of the d2 function an imperative. The paper ...
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BACKGROUND Clustering is a key step in the processing of Expressed Sequence Tags (ESTs). The primary goal of clustering is to put ESTs from the same transcript of a single gene into a unique cluster. Recent EST clustering algorithms mostly adopt the alignment-free distance measures, where they tend to yield acceptable clustering accuracies with reasonable computational time. Despite the fact th...
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